Circulating phospholipase-A2 activity in tonsillar hyperplasia and chronic tonsillitis in children

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Circulating phospholipase-A2 activity in tonsillar hyperplasia and chronic tonsillitis in children
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  Conclusion:  Urine KS level varied with and age and clinicalseverity. Keywords:  MPs, GAGs, Keratan sulfatedoi:10.1016/j.clinbiochem.2011.08.418 Poster   –  [A-10-898-1]Circulating phospholipase-A2 activity in tonsillar hyperplasia andchronic tonsillitis in children Rana Ezzeddini, Masoud Darabi, Nadereh Rashtchizadeh,Babollah Ghasemi, Yalda Jabbari-Moghaddam, Maghsod Shaaker,Masoud Ansarin, Akbar Samadi, Solmaz Madadi, Habib Sadeghi,Roghayeeh Safarzadeh, Ravan Jamal Karam Tabriz University of Medical Sciences, Tabriz, IranE-mail address:  mdarabi@hotmail.com (M. Darabi) Introduction:  Phospholipase A2 (PLA2) plays a major role ingrowth regulation, differentiation and inflammation. It has beenproposed as an evaluating marker for infection and inflammation.The aim of this study was to investigate activity of serum PLA2 intonsillar hyperplasia and chronic tonsillitis. Materials and Methods:  Activity of serum PLA2 was determined inchildren who underwent tonsillectomy, 126 had hyperplasia and 60chronic tonsillitis. Serum enzyme activities were measured using thestandard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate. Results:  The PLA2 activity of serum was significantly higher inchronictonsillitisthanintonsillarhyperplasia(P<0.001).Ageandbodymass index were not different between these two groups and wereunalteredbygender.Whenmalesandfemaleswereanalyzedseparately,thesameassociationwasobservedinmales(P=0.006)butnotfemales(P=0.06). Conclusion:  An increased serum PLA2 activity was observed inpatients with chronic tonsillitis compared to those with tonsillarhyperplasia. The results provide evidence that serum PLA2 activitymay have potential as a diagnostic marker for patients with chronictonsillitis, likely to be modulated by female gender. Keywords:  Tonsillar hyperplasia, Tonsillitis, PLA2doi:10.1016/j.clinbiochem.2011.08.419 Poster   –  [A-10-906-1]Plasma concentration of cholesterol, triglyceride, HDL-C, LDL-C, ApoA1, Apo B and Lp(a) during the menses, follicular and lutealphases of the menstrual cycle  Jamshid Karimi, Heidar Tavilani, Amir Fattahi Department of Biochemistry, Medical School, Hamadan University,Hamadan, IranE-mail addresses:  jmshdkarimi@yahoo.com (J. Karimi),tavilani@gmail.com (H. Tavilani),amir.fattahi89@gmail.com (A. Fattahi) Introduction:  Investigations on variation of lipids and lipopro-teins are very important because they are risk factor for cardiovas-cular disease. The influence of menstrual cycle on plasma lipid andlipoprotein levels has not been extensively investigated. Materials and Methods:  The purpose of this study was todetermine the levels of triglyceride, total cholesterol, HDL-C, LDL-C,ApoA1, Apo B and Lp(a) during the menses, follicular and lutealphases of the menstrual cycle in twenty women. Results:  Our results showed the levels of triglyceride, cholesterol,LDL-C, Apo B and Lp(a) of follicular phase were higher than lutealphase (p<0.01). In addition, level of HDL-C and ApoA1 of follicularphase were lower than luteal phase (p<0.01). Conclusions:  These findings support idea that the luteal comparedwith the follicular phase has a lipid and lipoprotein profile thatassociated with decreased coronary heart disease (CHD) risk. Also,weconclude that differences in lipid profile between menstrual cyclephases need to be considered in the screening and medical monitoringof premenopausal women, especially those with borderline levels. Keywords:  Lipids, Menstrual cycle, Sex hormonesdoi:10.1016/j.clinbiochem.2011.08.420 Poster   –  [A-10-908-1]Kinetic of ischemia modified albumin in the acutecoronary syndrome Mohammad Ali Takhshid, Sara Heidary Shiraz University of Medical Sciences, Shiraz, IranE-mail addresses:  Takhshid2001@yahoo.co.uk (M.A. Takhshid),heidari_sara@yahoo.com (S. Heidary) Introduction:  Ischemia modified albumin (IMA) is a marker of cardiac ischemia. The aim of the investigationwas to studychanges inthe serum level of IMA over time in patients with acute coronarysyndrome (ACS). Methods:  55 ACS patients presenting to emergency departmentwere divided into ST elevation -acute coronary syndrome (STE-ACS,n=12) and non ST elevation- acute coronary syndrome (NSTE-ACS,n=33) according to their final diagnosis,retrospectively. Five bloodsamples were taken at 0, 6,12, 24 h following admission. Serum IMAlevels were measured in the samples. Results:  There was no significant difference between IMA levelsbetween STE-ACS and NSTE-ACS patients in the all samples. Thehighest concentration of IMA levels were in the first sample in bothgroup (STE-ACS: 112±29 U/ml; NSTE-ACS: 109±25 U/ml). IMAdecreased gradually and after 12 h returned to normal in both group. Conclusion:  Results of this study showed that IMA had rapid riseand kinetic in serum of ACS patients. Early IMA increase may beuseful for early triage of ACS patients however; rapid kinetic may bedecreasing its clinical utility. Keywords:  Ischemia modified albumin, Kinetic, Acute coronarysyndromedoi:10.1016/j.clinbiochem.2011.08.421 Poster   –  [A-10-916-4]Immune response profile in Hesperidin treated mice suffering from experimental autoimmune encephalomyelitis Dariush Haghmorad, Abbas Ali Amini, Mohammad Bagher Mahmoudi,Samaneh Soltani, Nafise Tabasi, Zoleikha Jalayer,Maryam Rastin, Mahmoud Mahmoudi Mashhad University of Medical Sciences, Mashhad, IranE-mail addresses:  dhaghmorad@gmail.com (D. Haghmorad),MahmoudiM@mums.ac.ir (M. Mahmoudi) Introduction:  Multiple sclerosis (MS) is the most common centralnervous system inflammatory disease, which is due to the reaction of auto-reactive T cells with myelin proteins, leading to physical disorderand paralysis among people suffering the disease. Experimentalautoimmune encephalomyelitis (EAE) is used as an animal model of this disease.  Abstracts S166
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